515814-01-4 Voclosporin

Sifat

Penampilan putih menjadi padat putih
Titik mendidih: 13 0 3.8 ± 65.0 darjah
Ketumpatan 1. 0 16 ± 0.06 g/cm3
Tempatan Penyimpanan. Simpan di -20 ijazah
kelarutan benzena (sedikit), metanol (sedikit)
PKA13.32 ± 0. 70
 

Permohonan:

Voclosporin adalah inhibitor fosfatase yang dikawal oleh kalsium novel, secara struktural sama dengan cyclosporine A. Selepas pengubahsuaian, aktivitinya meningkat sebanyak 3-4 kali, dan ia mempunyai mekanisme dwi dan sinergi. Dengan menghalang fosfatase yang dikawal selia kalsium, ia boleh menghalang ekspresi IL -2 dan tindak balas imun sel-mediasi sel, menstabilkan podosit buah pinggang. Berbanding dengan cyclosporine, vocyclosporine juga mempunyai kelebihan kesan yang kurang terhadap kolesterol dan trigliserida, dan risiko diabetes yang lebih rendah.

 

Sinonim:

Voclosporin

515814-01-4

Luveniq

Lupkynis

Voclosporine

Voclosporina

R 1524

R-1524

(3s, 6s, 9s, 12r, 15s, 18s, 21s, 24s, 30s, 33s) -30- ethyl -33- [(1r, 2r, 4e) -1- Hydroxy -2- m Ethylhepta -4, 6- dienyl] -1, 4,7,10,12,15,19,25, 28- nonamethyl -6, 9,18, {3 1}} tetrakis (2- methylpropyl) -3, 21- di (propan -2- yl) -1, 4,7,10,13,16,19,2 2,25,28, 31- UndecazacyClotritriaContane -2, 5,8,11,14,17,20,23,26,29, 32- undecone

Voclosporin-D4

Cyclosporin A, 6- ((2s, 3r, 4r) -3- hydroxy -4- metil -2- (methylamino) -6

(3s, 6s, 9s, 12r, 15s, 18s, 21s, 24s, 30s, 33s) -30- ethyl -33- ((1r, 2r, e) -1- Hydroxy {{15 }} methylhepta -4, 6- dien -1- yl) -6, 9,18, 24- Tetraisobutyl -3 Diisopropyl -1, 4,7,10,12,15,19,25, 28- nonamethyl -1, 4,7,10,13,16,19,225, 28, 31- undecaazacyclotritriacontan -2, 5,8,11,14,17,20,23,26,29, 32- undecaOne

Cyclo (((E, z)-(2s, 3r, 4r) -3- hydroxy -4- methyl -2- (methylamine) nona -6, {8}} dienoyl) -l {} L-n-methyl-l-leucyl-l-valyl-n-methyl-l-leucyl-l-alanyl-d-alanyl-n-methyl-l-leucyl-n-methyl-l-leucyl-n-methyl-l-valil)

Voclosporinum

Lupkynis

1, 11- anhydro (l-alanyl-d-alanyl-n-methyl-l-leucyl-n-methyl-l-leucyl- N-methyl-l-valil-((2s, 3r, 4r, 6e) -3- hydroxy -4- metil - 2- (methylamino) nona -6 N-methylglycyl-n-methyl-l-leucyl-l-valyl-n-methyl-l-leucine)

Lx -214

Isatx -247; Luveniq

6- [(2s, 3r, 4r, 6e) -3- hydroxy -4- methyl -2- (methylamino) -6, 8- nonadienoic acid] cyclosporin a

Voclosporin

EX-A5922

AT27977

(3s, 6s, 9s, 12r, 15s, 18s, 21s, 24s, 30s, 33s) -30- ethyl -33- ((1r, 2r, e) -1- Hydrox y -2- methylhepta -4, 6- dien -1- yl) -6, 9,18, 24- Tetraisobutyl {{{{{{{ 23}}, 21- diisopropyl -1, 4,7,10,12,15,19,25, 28- nonamethyl -1, 4,7,10 , 13,16,19,22,25,28, 31- undecaazacyclotritriacontan -2, 5,8,11,14,17,20,23

6- [(2s, 3r, 4r, 6e) -3- hydroxy -4- methyl -2- (methylamino) -6

Cyclo (l-alanyl-d-alanyl-n-methyl-l-leucyl-n-methyl-l-leucyl-n-methyl-l-valil- ((2s, 3r, 4r, 6e) -3- hydroxy -4- metil -2- (methylamino) nona -6, 8- Dienoyl)-(2s) -2- Aminobutanoyl-n-methylglycyl-n-methyl-l-leucyl-l-valyl-n-methyl-l-leucyl)

Cyclo (l-alanyl-d-alanyl-n-methyl-l-leucyl-n-methyl-l-leucyl-n-methyl-l-valil-((2s, 3r, 4r, 6e) -3- hydroxy -4- methyl {}}

 

Cool tags: 515814-01-4 Voclosporin, China 515814-01-4 Pengilang Voclosporin, Pembekal, API Auggmented အဖြစ်မှန်ပေါင်းစည်းမှု, API ရရှိနိုင်မှု, API E-Commerce Platform API ပေါင်းစည်းမှု, API ကျန်းမာရေးစောင့်ရှောက်မှု API ပေါင်းစည်းမှု, API JSON format, API ထုတ်လုပ်မှု API ပေါင်းစည်းမှု